abstract：:This descriptive study of 55 outpatients with unipolar major depression compared placebo responders (n = 21) and placebo nonresponders (n = 34) with respect to demographic, diagnostic, history of illness and symptomatic features of the current episode of depression. Placebo responders were significantly more likely to...

journal_title：Psychiatry research

authors： Fairchild CJ,Rush AJ,Vasavada N,Giles DE,Khatami M

更新日期：1986-07-01 00:00:00

abstract：:A study of weight change in subjects treated with imipramine was performed on recurrent depressive outpatients. The patients (n = 52) were treated with imipramine (200-250 mg/day) and psychotherapy for 16 weeks. Each individual was weighed upon entry to the study (drug-free) and then weekly thereafter for 16 weeks. Of...

journal_title：Psychiatry research

authors： Fernstrom MH,Krowinski RL,Kupfer DJ

更新日期：1986-04-01 00:00:00

abstract：:A computed tomographic (CT) brain scan study was conducted in 24 young males treated and followed up for hyperactivity since childhood. Compared to 27 matched controls, adults with a history of hyperactivity had a significantly greater frequency of cerebral atrophy. No differences in cerebellar atrophy frequency or in...

journal_title：Psychiatry research

authors： Nasrallah HA,Loney J,Olson SC,McCalley-Whitters M,Kramer J,Jacoby CG

更新日期：1986-03-01 00:00:00

abstract：:New methods for determination of specific concentration and molecular activity of monoamine oxidase (MAO) in platelets are described and evaluated in parallel with specific activity measures, performed in whole platelets and platelet extracts. Platelet MAO specific concentration is determined in platelet extracts by a...

journal_title：Psychiatry research

authors： Fritz RR,Abell CW,Denney RM,Denney CB,Bessman JD,Boeringa JA,Castellani S,Lankford DA,Malek-Ahmadi P,Rose RM

更新日期：1986-02-01 00:00:00

abstract：:Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in nine male chronic cannabis users. The rCBF level in cannabis users was significantly (11%) lower than that of age- and sex-matched healthy controls. Four of the subjects were reexamined after 9-60 days of detoxification and showed a ...

journal_title：Psychiatry research

authors： Tunving K,Thulin SO,Risberg J,Warkentin S

更新日期：1986-01-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity appears to be correlated to certain diagnostic subgroups and symptom patterns. A group of criminal offenders hospitalized for forensic psychiatric assessment were studied. Male nurses and construction workers were used as controls. Patients who were diagnosed as psychopaths ac...

journal_title：Psychiatry research

authors： Lidberg L,Modin I,Oreland L,Tuck JR,Gillner A

更新日期：1985-12-01 00:00:00

abstract：:Several recent studies in animals and man indicate that corticosteroids may alter catecholaminergic activity in both the peripheral and central nervous systems. We administered 1 mg of the synthetic glucocorticoid, dexamethasone, to 12 drug-free healthy volunteers and measured plasma homovanillic acid (HVA) and 3-meth...

journal_title：Psychiatry research

authors： Wolkowitz OM,Sutton ME,Doran AR,Labarca R,Roy A,Thomas JW,Pickar D,Paul SM

更新日期：1985-10-01 00:00:00

abstract：:Twenty-one unmedicated, sequentially admitted psychiatric patients of either sex and four male healthy volunteers were given an intravenous injection of 2.5 mg morphine. Blood samples were drawn immediately before and at 30-minute intervals for 3 hours after the injection and assayed for cortisol. Morphine suppressed ...

journal_title：Psychiatry research

authors： Zis AP,Haskett RF,Albala AA,Carroll BJ,Lohr NE

更新日期：1985-06-01 00:00:00

abstract：:Plasma free homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured before drug treatment in 29 patients diagnosed as having major depression with melancholia and in 18 control subjects. Plasma HVA was significantly elevated in the total group of female melancholic patients when compared with ...

journal_title：Psychiatry research

authors： Devanand DP,Bowers MB Jr,Hoffman FJ Jr,Nelson JC

更新日期：1985-05-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) were determined in 40 drug-free schizophrenic patients and 21 healthy volunteers by a mass fragmentographic method. Twenty-one of the schizophrenic patients were first admissions who had never received neuroleptics. Sign...

journal_title：Psychiatry research

authors： Lindström LH

更新日期：1985-04-01 00:00:00

abstract：:Increased serotonergic activity in animals has been associated with a variety of stereotyped motor behaviors. In addition, serotonin facilitates brainstem, reticular, and spinal motor neuronal activity implicated in the expression of these behaviors. This report presents positive correlations between both peripheral (...

journal_title：Psychiatry research

authors： King R,Faull KF,Stahl SM,Mefford IN,Thiemann S,Barchas JD,Berger PA

更新日期：1985-03-01 00:00:00

abstract：:The pain sensitivity of 18 patients with panic disorder and age- and sex-matched controls was assessed by signal detection analysis. The authors failed to demonstrate any difference in pain sensitivity between the two groups. The relationship between state anxiety, as assessed by the Spielberger scale, and pain in pan...

journal_title：Psychiatry research

authors： Roy-Byrne P,Uhde TW,Post RM,King AC,Buchsbaum MS

更新日期：1985-01-01 00:00:00

abstract：:Higher electromyographic (EMG) activity levels of corrugator and zygomatic face muscles have been reported to be pretreatment predictors of better clinical outcome in depressed patients. We tested this possibility in 29 drug-free, rigorously diagnosed subjects by measuring low-level EMG activity of corrugator and zygo...

journal_title：Psychiatry research

authors： Greden JF,Price HL,Genero N,Feinberg M,Levine S

更新日期：1984-12-01 00:00:00

abstract：:Controversy exists regarding the association of age with postdexamethasone serum cortisol levels. We evaluated this relationship in 95 patients with major depressive disorder and 49 healthy controls. Age and 8 a.m. postdexamethasone cortisol levels were not correlated among the healthy controls, but were positively as...

journal_title：Psychiatry research

authors： Lewis DA,Pfohl B,Schlechte J,Coryell W

更新日期：1984-11-01 00:00:00

abstract：:Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects we...

journal_title：Psychiatry research

authors： Le Quan-Bui KH,Plaisant O,Leboyer M,Gay C,Kamal L,Devynck MA,Meyer P

更新日期：1984-10-01 00:00:00

abstract：:Increasing evidence implicates altered dopamine function in major affective illness. In the present study, growth hormone responses to the dopamine agonist apomorphine were not different for 14 male depressed patients and 16 healthy male volunteers. Baseline and post-apomorphine prolactin levels were lower for the dep...

journal_title：Psychiatry research

authors： Jimerson DC,Cutler NR,Post RM,Rey A,Gold PW,Brown GM,Bunney WE Jr

更新日期：1984-09-01 00:00:00

abstract：:Low levels of cerebrospinal fluid 5-hydroxyindoleacetic acid and a blunted thyroid-stimulating hormone response to thyrotropin-releasing hormone have been reported in depressed patients--in particular in those who have made violent suicide attempts. There are at least two conceivable explanations for these findings: T...

journal_title：Psychiatry research

authors： van Praag HM,Plutchik R

更新日期：1984-08-01 00:00:00

abstract：:To evaluate the influence of weight loss on the dexamethasone suppression test (DST), we studied 61 patients with major depressive disorder as defined by the Research Diagnostic Criteria, 59 healthy normal volunteers, and 16 volunteers who lost weight by dieting. Nonsuppression on the DST was not correlated to weight ...

journal_title：Psychiatry research

authors： Yerevanian BI,Baciewicz GJ,Iker HP,Privitera MR

更新日期：1984-06-01 00:00:00

abstract：:The cognitive effects of the specific norepinephrine (NE) uptake inhibitor desmethylimipramine (DMI) were examined in normal subjects. Although there were no differences in performance on drug compared to placebo treatment, there was an improvement in cognition 1 week after the drug had been discontinued. On DMI, ther...

journal_title：Psychiatry research

authors： Ross RJ,Smallberg S,Weingartner H

更新日期：1984-05-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity and intellectual level were examined in a large series of 1,129 18-year-old boys, selected from the general population. Personality traits were determined by means of selected subscales from several personality inventories such as the Zuckerman Sensation Seeking Scale, the Eys...

journal_title：Psychiatry research

authors： von Knorring L,Oreland L,Winblad B

更新日期：1984-05-01 00:00:00

abstract：:Social separation is a risk factor for major depressions that can be modeled in nonhuman primates. Changes in central monoamine neurotransmission are also likely to be involved in major depression. This study examined the relationship between separation-induced depressive-like behavior and central monoamine neurotrans...

journal_title：Psychiatry research

authors： Kraemer GW,Ebert MH,Lake CR,McKinney WT

更新日期：1984-04-01 00:00:00

abstract：:A great deal of variation in opinion and practice remains regarding the most efficient use of electroconvulsive therapy (ECT) in treating depression. In this study we used an estimate of maximal improvement point to look at the rate of response to conventional ECT (one seizure per session, three times per week) in 66 ...

journal_title：Psychiatry research

authors： Rich CL,Spiker DG,Jewell SW,Neil JF,Black NA

更新日期：1984-03-01 00:00:00

abstract：:Phodopus sungorus, the Siberian dwarf hamster, exhibits a number of reproducible and quantifiable behavioral changes when the members of a male-female pair bond are separated. Preliminary evaluation of the syndrome revealed a significant increase in body weight, decrease in social interaction, and decrease in explorat...

journal_title：Psychiatry research

authors： Crawley JN

更新日期：1984-01-01 00:00:00

abstract：:The present study continues the examination of the personality styles in normal populations that have been described in the clinical literature. Earlier work has focused on behavioral, attitudinal, and cognitive components of the personality styles. The present study extends our exploration of the cognitive domain by ...

journal_title：Psychiatry research

authors： Magaro PA,Smith P,Ashbrook RM

更新日期：1983-10-01 00:00:00

abstract：:Twenty-two patients who met the Utah criteria for attention deficit disorder, residual type (hyperactivity, minimal brain dysfunction in adults) received an open trial of pargyline (Eutonyl). Of these 22 patients, 13 (59%) showed a moderate to marked therapeutic response. Clinically useful features of pargyline in the...

journal_title：Psychiatry research

authors： Wender PH,Wood DR,Reimherr FW,Ward M

更新日期：1983-08-01 00:00:00

abstract：:Following a drug-free placebo period lasting at least 1 week, 10 female and 11 male newly hospitalized schizophrenic patients received chlorpromazine (CPZ) 200 mg/day for 1 week and 400 mg/day the following week. Serum CPZ equivalent (CPZ-E) levels were measured at the end of each week of CPZ treatment with a radiorec...

journal_title：Psychiatry research

authors： Meltzer HY,Busch DA,Fang VS

更新日期：1983-08-01 00:00:00

abstract：:This study compared basal concentrations of plasma beta-endorphin/beta-lipotropin-like immunoreactivity and dexamethasone suppression of cortisol in seven chronic pain patients, seven psychiatric disorder patients, and seven normal volunteers. Pain patients and psychiatric patients showed significantly higher basal co...

journal_title：Psychiatry research

authors： Atkinson JH,Kremer EF,Risch SC,Morgan CD,Azad RF,Ehlers CL,Bloom FE

更新日期：1983-08-01 00:00:00

abstract：:Chronic imipramine administration decreases the density of serotonin S2 and beta-adrenergic receptors. The mode of action is not clear but might be assumed to be a result of imipramine interacting with its high affinity binding sites on presynaptic serotonin neurons. To investigate this possibility and the role of the...

journal_title：Psychiatry research

authors： Dumbrille-Ross A,Tang SW

更新日期：1983-07-01 00:00:00

abstract：:Plasma levels of homovanillic acid (HVA), a dopamine metabolite, were examined in 19 psychiatric inpatients during maintenance treatment on neuroleptic medications. A significant positive correlation was found between the level of HVA and the severity of tardive dyskinesia (TD) in these patients. Seven patients had th...

journal_title：Psychiatry research

authors： Kirch D,Hattox S,Bell J,Murphy R,Freedman R

更新日期：1983-07-01 00:00:00

abstract：:Ninety-five patients hospitalized for acute psychosis were reviewed with respect to hallucinogen use and family history of mental illness. Sixty-three percent of admissions had used hallucinogens to some degree within 3 years of the index admission. Drug users were predominantly male, although no age or diagnostic dif...

journal_title：Psychiatry research

authors： Bowers MB Jr,Swigar ME

更新日期：1983-06-01 00:00:00

abstract：:Simple reaction time (SRT) was measured in schizophrenic, bipolar affective disorder, and never-psychotic outpatients to determine the specificity of SRT crossover to schizophrenia. A crossover pattern like that reported in other studies was found among the schizophrenics, but the average curve was not different from ...

journal_title：Psychiatry research

authors： Bohannon WE,Strauss ME

更新日期：1983-05-01 00:00:00

abstract：:The planimetric measurement of the area of the ventricles on a computed tomographic section is a convenient and useful method of assessing ventricular size when more sophisticated techniques are not available. It is commonly reported as a planimetric ventricular-brain ratio or VBR. Ventricular size is related to crani...

journal_title：Psychiatry research

authors： Zatz LM,Jernigan TL

更新日期：1983-03-01 00:00:00

abstract：:Endogenous opiates have been implicated as regulators of mood and pain. Recent literature suggests a relationship between these internal opiates and ingestive behaviors in both animals and humans. The present study investigates this relationship by comparing the pain sensitivities of obese and nonobese subjects. Twent...

journal_title：Psychiatry research

authors： McKendall MJ,Haier RJ

更新日期：1983-02-01 00:00:00

abstract：:Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented versus non-presented words of...

journal_title：Psychiatry research

authors： Cohen RM,Cohen MR,Weingartner H,Pickar D,Murphy DL

更新日期：1983-02-01 00:00:00

abstract：:This study investigates the role of endogenous opioids in the regulation of pain in humans. Two groups of healthy volunteers were subjected to different stress situations (cold pressor and arithmetic). In a double-blind design the changes in pain tolerance after stress were measured after an injection of either 0.8 mg...

journal_title：Psychiatry research

authors： Jungkunz G,Engel RR,King UG,Kuss HJ

更新日期：1983-01-01 00:00:00

abstract：:The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity bein...

journal_title：Psychiatry research

authors： Rice J,McGuffin P,Shaskan EG

更新日期：1982-12-01 00:00:00

abstract：:Four groups of children referred for attention disorders, learning disorders, or both were blindly titrated at statistically equivalent dosage levels of methylphenidate and improved more or less equivalently on several measures of attentiveness (cognitive style tests and reaction time). Methylphenidate dosage needs, w...

journal_title：Psychiatry research

authors： Ackerman PT,Dykman RA,Holcomb PJ,McCray DS

更新日期：1982-10-01 00:00:00

abstract：:Beta-Endorphin (0.3 or 0.6 nanomoles) was infused into the A10-ventral tegmental area (VTA) of male Wistar rats previously treated for 6 days with either morphine sulfate or lactose via subcutaneously implanted silastic pellets. Beta-Endorphin microinfusions occurred at 24 and 96 hours after pellets were removed. Prof...

journal_title：Psychiatry research

authors： Schwartz JM,Ksir C,Koob GF,Bloom FE

更新日期：1982-10-01 00:00:00

abstract：:The prevalence of symptoms of anorexia nervosa among students majoring in the areas of dance, drama, physical education, and English was determined by using the Eating Attitudes Test (EAT). It was hypothesized that female students who might be prone to develop anorexia nervosa as indicated by anorectic symptoms on the...

journal_title：Psychiatry research

authors： Joseph A,Wood IK,Goldberg SC

更新日期：1982-08-01 00:00:00

abstract：:Alteration in the hypothalamic-pituitary-adrenal (HPA) axis occurs in up to 50% of depressed patients and is demonstrated by the failure to suppress cortisol concentrations after dexamethasone administration. Evidence suggesting that these cortisol abnormalities reflect hypothalamic-pituitary dysfunction has been inco...

journal_title：Psychiatry research

authors： Kalin NH,Weiler SJ,Shelton SE

更新日期：1982-08-01 00:00:00